Specimen collection for evaluating hepatic function requires careful attention to detail, starting with the appropriate collection vessel. The external coating of these tubes is color-coded to signify the presence of specific additives which preserve the sample and/or initiate the separation of serum or plasma. Using the correct container is essential for accurate and reliable results. For example, if a test requires serum, a tube with a clot activator is typically used, while plasma-based assays necessitate tubes containing anticoagulants such as EDTA or heparin.
The accuracy of assessing liver health via laboratory analysis relies heavily on proper specimen handling from the point of collection to analysis. Choosing the right container ensures that the sample is processed correctly, preventing pre-analytical errors like clotting, hemolysis, or additive interference, all of which can lead to skewed results. Historically, inaccuracies in testing stemming from improper collection methods have necessitated repeat testing, leading to delays in diagnosis and increased costs.
